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Nevertheless, this doesn't preclude the likelihood that these adjustments would possibly turn out to be permanent with more prolonged AAS use or with repeated cycles that provide too little time for restoration to take place in between. This is especially worrisome as there is appreciable evidence that myocardial harm, which may accumulate in years of ongoing AAS use, is a primary cause for sudden cardiac demise in AAS users (217). Since massive doses of AAS are administered throughout an AAS cycle, it's evident that the development of gynecomastia during AAS use isn't the end result of an absolute or relative deficiency of androgenic action. Estradiol levels increase dose-dependently with testosterone administration

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